Combined treatment of giant cell bone tumor

Introduction. Giant cell tumor refers to tumors with an uncertain malignancy potential, has a locally aggressive  course. Intra-focal resections performed for a giant cell tumor of long tubular bones are accompanied by the development of relapse in 30–46 % of cases. The combination of pathogenetic therapy with surgical intervention makes it  possible to reduce the frequency of relapses in operable tumors after marginal and intra-focal resections, and in inoperable tumors to provide local control and relieve pain.  Objective – to analyze the results of combined treatment of patients with giant cell bone tumor.  Materials and methods. In the conditions of Republican Clinical Oncological Dispensary of the Ministry of Health  of the Republic of Tatarstan, 13 patients aged 20 to 63 years are in the process of combined treatment of a giant cell  tumor. As of November 2021, 7 patients have completed treatment.Results. Among the 7 patients who completed treatment, 6 people were operated on (1 patient refused surgery).  In 5 patients, intra-focal resection of the tumor with osteoinductive material “BoneMedic-S” was performed, in 1 patient with a giant cell tumor of the sciatic bone, resection of the sciatic bone was performed without reconstruction.  1 patient with a widespread tumor (sacral lesion) receives supportive treatment.  Conclusion. The combined approach in the treatment of giant-cell bone tumor allows performing a functional-saving, organpreserving surgical intervention, significantly reducing the risk of tumor recurrence and its malignant transformation.