The Role of LncRNA MALAT-1 and MiRNA-9 in Psoriasis

Abstract Background: Psoriasis is a chronic skin disorder manifested by recurrent episodes of scaly, red, itchy skin patches that occur within apparently normal skin. Objectives: This study was performed to detect the expression of serum and tissue (lesion and non-lesion) LncRNA MALAT-1 and MiRNA-9 that might be used as biomarkers for psoriasis. Methods: 100 subjects were included in this study, 60 psoriatic patients as well as 40 controls, blood samples were taken from all subjects, 4 mm punch biopsy was taken from lesional and non lesional skin of psoriatic patient and controls. Expression of LncRNA MALAT-1 and miRNNA-9 in Serum and tissues was detected by real time qRT-PCR.Results: our results revealed a statistically significant increase in the expression of MALAT-1 in lesional and non-lesional skin and serum of psoriatic patients than controls. Also there was statistically significant increase in serum MiRNA-9 in patients than controls. Meanwhile, its tissue level was significantly decreased in patients than controls.Conclusion: This study highlights the contribution of LncRNA MALAT-1and miRNA-9 in the pathogenesis of psoriasis. Elevated expression of MALAT-1 in lesional skin of psoriatic patients compared to non-lesional skin is probably an important factor in the development of psoriatic plaques.