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Emergence of an inhibitor-resistant beta-lactamase (SHV-10) derived from an SHV-5 variant
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An inhibitor-resistant beta-lactamase (SHV-10), derived from an SHV-5 variant (SHV-9), was found in an Escherichia coli clinical isolate. In SHV-10, Ser-130 was replaced by Gly. The enzyme partially retained its ability to hydrolyze penicillins, but its activity against cephalosporins was drastically reduced. A Ser-130-->Gly mutant of the prototype SHV-5, obtained by site-directed mutagenesis, had properties similar to those of SHV-10.
American Society for Microbiology
Title: Emergence of an inhibitor-resistant beta-lactamase (SHV-10) derived from an SHV-5 variant
Description:
An inhibitor-resistant beta-lactamase (SHV-10), derived from an SHV-5 variant (SHV-9), was found in an Escherichia coli clinical isolate.
In SHV-10, Ser-130 was replaced by Gly.
The enzyme partially retained its ability to hydrolyze penicillins, but its activity against cephalosporins was drastically reduced.
A Ser-130-->Gly mutant of the prototype SHV-5, obtained by site-directed mutagenesis, had properties similar to those of SHV-10.
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