Solitary intracerebral Langerhans cell histiocytosis

Background: Langerhans cell histiocytosis is an uncommon proliferative histiocytic disorder which can affect any organ. It is common in children and can rarely occur in adults. In the central nervous system, the hypothalamic-pituitary axis is most commonly involved. Brain parenchyma is rarely affected. Case summary: We report a case of a 13-year-old male who presented with chief complaints of headache and swelling over the right frontal region. On imageology, a clinical diagnosis of meningioma was considered. The tumor was excised and on histopathological examination diagnosis of Langerhans cell histiocytosis was considered Conclusion: Intracranial Langerhans cell histiocytosis is a rare condition which can mimic primary neoplasms of the central nervous system such as glioma, meningioma and metastatic deposits on imageology. Histopathology is the gold standard for diagnosis.