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Suppression of β-Cell Apoptosis from H2O2-Induced Oxidative Stress in MIN6 cells using Methyl Gallate
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A major parameter for diabetic relevant diseases and hyperglycemia is the β-cell apoptosis. Anti diabetic drugs used widely these days chiefly target to lower hyperglycemia along with prevention of β-cells from apoptosis. In this study three natural products methyl gallate, syringic acid, and butanedioic acid from Myricaria germanica were analyzed for β-cell protection. Methyl gallate provided significant β-cell protection from H2O2-induced oxidative stress mediated apoptosis in MIN6 cells at 50 μM (95.5% and#177; 16.0 vs 57.6% and#177; 1.1) and at 100 μM (85.5% and#177; 7.0 vs 57.6% and#177; 1.1) concentrations.
Title: Suppression of β-Cell Apoptosis from H2O2-Induced Oxidative Stress in MIN6 cells using Methyl Gallate
Description:
A major parameter for diabetic relevant diseases and hyperglycemia is the β-cell apoptosis.
Anti diabetic drugs used widely these days chiefly target to lower hyperglycemia along with prevention of β-cells from apoptosis.
In this study three natural products methyl gallate, syringic acid, and butanedioic acid from Myricaria germanica were analyzed for β-cell protection.
Methyl gallate provided significant β-cell protection from H2O2-induced oxidative stress mediated apoptosis in MIN6 cells at 50 μM (95.
5% and#177; 16.
0 vs 57.
6% and#177; 1.
1) and at 100 μM (85.
5% and#177; 7.
0 vs 57.
6% and#177; 1.
1) concentrations.
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