Short-Term Changes Detected by Corneal Topography and Optical Coherence Tomography After Prophylactic Laser Iridotomy in Primary Angle Closure Suspect

Abstract Purpose: To evaluate early changes in anterior segment parameters by Scheimpflug-Placido disc topography system and changes in retinal layers by optical coherence tomography in primary angle-closure suspects after laser peripheral iridotomyMethods: One eye of 26 patients with primary angle closure suspect and of 20 healthy subjects were included in this retrospective cross-sectional study. Anterior chamber depth/volume, iridocorneal angle and central corneal thickness were obtained by Scheimpflug-Placido disc topography system. Retinal thickness, retinal nerve fiber layer thickness and ganglion cell-inner plexiform layer thickness were acquired by optical coherence tomography. All the tests were repeated 1 week and 1 month after laser peripheral iridotomy.Results: The mean ages of the patients and healthy controls were 64.8±10.7 years and 64.5 ± 3.9 years, respectively (p=0.990). Anterior chamber depth/volume and iricorneal angle value were lower in the PACS group (p<0.001, for all). Anterior chamber volume and iridocorneal angle increased significantly after laser peripheral iridotomy (p=0.004, for both). While foveal thickness decreased significantly after laser peripheral iridotomy (p=0.027), retinal nerve fiber layer thickness increased in superior and temporal quadrants (p=0.038 and p=0.016, respectively).Conclusion: Our results suggest that LPI in patients with PACS provides improved retinal thickness and RNFL thickness, as well as anterior chamber parameters.