TINOSPORA CORDIFOLIA AND LOW DOSE ASPIRIN IN THE TREATMENT OF CHRONIC PERIODONTITIS

Aim: To compare the effectiveness of Tinospora cordifolia and low-dose aspirin in treating chronic periodontitis. Materials And Methods: The current study is a double-masked, randomized clinical trial. A total of thirty patients of age 25 to 55 years were assigned randomly into two groups. After phase-I therapy, In Group A, Tinospora cordifolia (TC) (Guduchi- Himalayan company) tablets – 150mg, and in Group B, Low-dose aspirin (Ecospirin 75 – USV private limited)– 75mg was given adjunctively. At baseline and after six months in both groups, gingival index (GI), plaque index (PI), clinical parameters like periodontal probing depth (PPD) and clinical attachment level (CAL), and bone biomarker C- terminal telopeptide (serum β-CTX) were evaluated. Results: The results of the current trial showed that all subjects from the two groups had a signicant decrease in the GI, PI, and clinical parameters like PPD and CAL compared from baseline to six months. There was a signicant reduction in serum β-CTX levels after phase I therapy in chronic periodontitis subjects after host modulation with Tinospora cordifolia and low-dose aspirin. A positive correlation was shown between the clinical parameters and serum c levels in both groups. However, there was a statistically signicant decrease in the serum β-CTX levels in Tinospora cordifolia compared with the low-dose aspirin group. Conclusion: Tinospora cordifolia and low-dose aspirin both can be used as adjuncts to NSPT. The evaluation of bone resorption biomarker C – terminal telopeptide also helps in assessing the periodontal disease progression.