Self-activatable photodynamic-immunotherapy based on poly(thioketal) conjugated with photosensitizers

Photodynamic therapy is a non-invasive and controllable modality with potential as a novel cancer treatment strategy. However, the ROS production efficiency of PDT is restricted to hydrophobic characteristics and aggregation caused quenching of PSs. Herein, we designed a ROS self-activatable polymer (PTKPa) to suppress photosensitizers ACQ and elevate ROS production capacity. This platform shows therapeutic outcomes in both cells and orthotopic mouse model, which can significantly elevate the intracellular ROS level upon 660nm laser irradiation, induce immunogenic cell death (ICD) to activate antitumor immunity. This work provides a general strategy enhancing tumor photodynamic therapeutic effects.