Abstract 10465: Prevalence, Predictors and Outcomes of Pericardial Tamponade In Influenza Virus Infection: A Nationwide Inpatient Analysis

Introduction: Pericardial Tamponade (PT) is a rare, yet fatal complication of influenza virus infection (IVI). Considering the pertaining data remaining limited to case reports, we evaluated the frequency of PT and associated demographic variations, predictors and outcomes of PT in IVI using national multicenter datasets. Methods: We identified adult IVI admissions complicated by PT using National Inpatient Sample (2015Oct-2017) and relevant ICD-10 codes. Primary outcomes for frequency and predictors of PT in IVI and secondary outcomes of all-cause in-hospital mortality and patient discharge were analyzed. The multivariable analysis was performed adjusting for confounders to assess the independent predictors of PT in IVI. Results: Of 380,730 admissions with IVI, 130 (0.03%) patients experienced PT. Overall, young, female, non-white patients more frequently suffered PT during admissions for IVI. Compared to IVI admissions without PT, admissions with PT had significantly nearly six times higher all-cause mortality (23.1% v. 3.4 %, p<0.001). IVI-PT cohort had fewer routine discharges compared to those without PT (30.8% vs. 59.8%, p<0.001). IVI-related admissions who were Hispanics (OR 2.85 [CI 1.66-4.89] p<0.001) in highest income quartile (OR 4.02 [CI 2.40-6.74] p<0.001) with comorbidities like metastatic cancer(OR 6.60 [CI 3.70-11.79] p<0.001), peripheral vascular disease (OR 4.69 [CI 2.65-8.29] p<0.001), prior radiation therapy (OR 3.66 [CI 1.38-9.70] p=0.009), congestive heart failure (OR 3.65 [CI 2.41-5.52] p<0.001), pulmonary circulation disease (OR 3.23 [CI 1.30-8.02] p=0.011), and obesity (OR 2.41 [CI 1.56-3.72] p<0.001) had higher odds of developing PT (Figure 1) . Conclusions: In this multicenter analysis, we found IVI-related admissions among non-whites, patients from high-income quartile with cardiometabolic and oncologic comorbidities had a higher prediction of PT on multivariate analysis.