An Ayurvedic concept of Shatkriyakala with special reference to Cancer Pathogenesis

Acharya Susruta describes about the various stages in the development of malignant tumors and also recognizes recurrence as well as metastasis. The concept of Shatkriyakala, is an objective approach of Ayurveda, which gives a sign about the consecutive phases of the disease for distinguishing the particular disease and to institute appropriate therapeutic intervention, and accordingly preventive measures can be described to overcome complications as well as advancement of the disease. Shatkriyakala, in which disease state is not an instantaneous occurrence, evolves through a sequence of certain phases in relation to the tridoshas-pathophysiologic rhythm. In respect to cancer pathogenesis, it is a hyper-proliferative disorder develops due to genetic dysregulation of growth of cells and tissues that encompasses many stages such as transformation, derange of apoptosis, proliferation, invasion, angiogenesis and metastasis (almost final stage). The physician must acquire the knowledge to recognize early stages of the diseases and accordingly initiate the needful management to contain the further progression of the diseases. In this article critically correlate the concept of Shatkriyakala (stages of progression of disease) in respect to cancer pathogenesis based on the probable involvement of tridoshas (Vata, Pitta and Kapha), Dushyas (dhatus, upadhatus & malas), Agni, Srotas etc.