Contrast-enhanced Ultrasound in Obstetrics and Gynecology

Abstract Ultrasonography is a well-established imaging modality for evaluation of gynecologic tumors. In recent years, more sophisticated technologies like the use of intravascular contrast agents led to an improvement in the ability of the practitioner to differentiate benign from malignant masses. When we consider the safety of contrast-enhanced ultrasonography in obstetrics and gynecology, we must discuss about the effect of ultrasound contrast media on embryo and fetus. The use of ultrasound contrast media in pregnant women always concerns in the obstetricians because of the principle of not exposing a fetus to any drug. Therefore, the literature was reviewed for information about those safety and efficacy because of the uncertainty about the use of contrast media during pregnancy. Based on the limited information available, mutagenic and teratogenic effects have not been described after administration of ultrasound contrast media. No effect on the fetus has been seen after contrast media. The small potential risk associated with the nonthermal bioeffects via acoustic cavitation may be considered to prohibit the use in first trimester pregnant women. In previous studies including human trials, no evidence of adverse effect was reported. Contrast-enhanced ultrasonography could prove a useful adjunct in multiple gestations and in evaluation of uteroplacental circulation. It appears to be very promising potential in obstetrics.