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Beyond Self-Resistance: ABCF ATPase LmrC Is a Signal-Transducing Component of an Antibiotic-Driven Signaling Cascade Accelerating the Onset of Lincomycin Biosynthesis
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Resistance proteins are perceived as mechanisms protecting bacteria from the inhibitory effect of their produced antibiotics or antibiotics from competitors. Here, we report that antibiotic resistance proteins regulate lincomycin biosynthesis in response to subinhibitory concentrations of antibiotics.
American Society for Microbiology
Title: Beyond Self-Resistance: ABCF ATPase LmrC Is a Signal-Transducing Component of an Antibiotic-Driven Signaling Cascade Accelerating the Onset of Lincomycin Biosynthesis
Description:
Resistance proteins are perceived as mechanisms protecting bacteria from the inhibitory effect of their produced antibiotics or antibiotics from competitors.
Here, we report that antibiotic resistance proteins regulate lincomycin biosynthesis in response to subinhibitory concentrations of antibiotics.
Related Results
Beyond self-resistance: ABCF ATPase LmrC is a signal-transducing component of an antibiotic-driven signaling cascade hastening the onset of lincomycin biosynthesis
Beyond self-resistance: ABCF ATPase LmrC is a signal-transducing component of an antibiotic-driven signaling cascade hastening the onset of lincomycin biosynthesis
Abstract
In natural environments, antibiotics are an important instrument of inter-species competition. At subinhibitory concentrations, they act...
ABCF ATPases involved in protein synthesis, ribosome assembly and antibiotic resistance: structural and functional diversification across the tree of life
ABCF ATPases involved in protein synthesis, ribosome assembly and antibiotic resistance: structural and functional diversification across the tree of life
AbstractWithin the larger ABC superfamily of ATPases, ABCF family members eEF3 inSaccharomyces cerevisiaeand EttA inEscherichia colihave been found to function as ribosomal transla...
Lincosaminides
Lincosaminides
AbstractLincomycin, C18H34N2O6S, the first lincosaminide antibiotic to which a structure was assigned, is defined chemically as methyl 6,8‐dideoxy‐6‐(1‐methyl‐trans‐4‐propyl‐L‐pyrr...
Evolution of Antimicrobial Resistance in Community vs. Hospital-Acquired Infections
Evolution of Antimicrobial Resistance in Community vs. Hospital-Acquired Infections
Abstract
Introduction
Hospitals are high-risk environments for infections. Despite the global recognition of these pathogens, few studies compare microorganisms from community-acqu...
V-ATPase Deficiency Aggravates Hypoxia-induced Spermatogenesis Reduction by Promoting Spermatocyte Apoptosis via the JNK/c-Jun Pathway in Mice
V-ATPase Deficiency Aggravates Hypoxia-induced Spermatogenesis Reduction by Promoting Spermatocyte Apoptosis via the JNK/c-Jun Pathway in Mice
Abstract
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Quality Assessment of Some Selected Generic Brands of Lincomycin Capsules Marketed in Gombe Metropolis
Quality Assessment of Some Selected Generic Brands of Lincomycin Capsules Marketed in Gombe Metropolis
Lincomycin is an antibiotic indicated for the treatment of serious infections and is reserved for use in cases of penicillin allergy. Several brands of lincomycin capsules are avai...
Association between Awareness on Antibiotic Resistance and Antibiotic Misuse Among Saudi University Students
Association between Awareness on Antibiotic Resistance and Antibiotic Misuse Among Saudi University Students
Background:
Saudi Arabia has the highest prevalence of resistant pathogens in the Gulf Region, with a rapid increase in antibiotic resistance seen in recent years. ...
Phenotypic and Molecular Characterization of the blaTEM Gene in Extended-Spectrum Beta-Lactamase-Producing Klebsiella pneumoniae
Phenotypic and Molecular Characterization of the blaTEM Gene in Extended-Spectrum Beta-Lactamase-Producing Klebsiella pneumoniae
Abstract
Introduction
There has been a notable rise in antibiotic resistance among enterobacteria. This issue is primarily attributed to the emergence of extended-spectrum beta-lac...