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The patient with Wilms tumour
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Wilms tumour is the most common renal tumour in childhood. It is most commonly identified as a large abdominal mass. Treatment by surgical removal and chemotherapy, and radiotherapy in more advanced stages, is curative in most patients. Five year survival is over 90%. Survivors may be at some risk from long term complications including the effects of radiotherapy on the remaining kidney.A small minority of Wilms tumours occur in individuals with an underlying mutation in the WT1 gene. WT1 mutations may also cause developmental abnormalities of the genitourinary system, and renal disease including steroid-resistant nephrotic syndrome / focal segmental glomerulosclerosis.
Title: The patient with Wilms tumour
Description:
Wilms tumour is the most common renal tumour in childhood.
It is most commonly identified as a large abdominal mass.
Treatment by surgical removal and chemotherapy, and radiotherapy in more advanced stages, is curative in most patients.
Five year survival is over 90%.
Survivors may be at some risk from long term complications including the effects of radiotherapy on the remaining kidney.
A small minority of Wilms tumours occur in individuals with an underlying mutation in the WT1 gene.
WT1 mutations may also cause developmental abnormalities of the genitourinary system, and renal disease including steroid-resistant nephrotic syndrome / focal segmental glomerulosclerosis.
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