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In Vitro Activity of Ceftolozane-Tazobactam against Multidrug-Resistant Nonfermenting Gram-Negative Bacilli Isolated from Patients with Cystic Fibrosis
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ABSTRACT
Ceftolozane-tazobactam was tested against 58 multidrug-resistant nonfermenting Gram-negative bacilli (35
Pseudomonas aeruginosa
, 11
Achromobacter xylosoxydans
, and 12
Stenotrophomonas maltophilia
isolates) isolated from cystic fibrosis patients and was compared to ceftolozane alone, ceftazidime, meropenem, and piperacillin-tazobactam. Ceftolozane-tazobactam was the most active agent against
P. aeruginosa
but was inactive against
A. xylosoxydans
and
S. maltophilia
. In time-kill experiments, ceftolozane-tazobactam had complete bactericidal activity against 2/6 clinical isolates (33%).
American Society for Microbiology
Title: In Vitro
Activity of Ceftolozane-Tazobactam against Multidrug-Resistant Nonfermenting Gram-Negative Bacilli Isolated from Patients with Cystic Fibrosis
Description:
ABSTRACT
Ceftolozane-tazobactam was tested against 58 multidrug-resistant nonfermenting Gram-negative bacilli (35
Pseudomonas aeruginosa
, 11
Achromobacter xylosoxydans
, and 12
Stenotrophomonas maltophilia
isolates) isolated from cystic fibrosis patients and was compared to ceftolozane alone, ceftazidime, meropenem, and piperacillin-tazobactam.
Ceftolozane-tazobactam was the most active agent against
P.
aeruginosa
but was inactive against
A.
xylosoxydans
and
S.
maltophilia
.
In time-kill experiments, ceftolozane-tazobactam had complete bactericidal activity against 2/6 clinical isolates (33%).
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