The antiaging cream characteristics from extract of turmeric (Curcuma domestica Val.) rhizome and tamarind (Tamarindus indica L.) leaves

Chemical-based cosmetics tend to have adverse side effects on human skin so that public awareness arises to use cosmetics made from natural ingredients that do not have side effects. Extract cream of turmeric and tamarind leaf is one of the cosmetics made from natural ingredients that has the potential to replace chemical-based cosmetics. This study aims to determine the hydrophilic lipophilic balance (HLB) value and perfume type to get the cream with the best characteristics, an extract mixture concentration of turmeric rhizome and tamarind leaves used in the manufacture of anti-aging cream, and its application. The experiment used randomized block design with HLB treatment: 9,10,11 and the perfume type : 1,5% jasmine, 2% champagne, 2% rose, while the mixed treatment of turmeric extracts and tamarind leaves extracts were used with the concentration of 0, 1, 2, 3, 4, 5%. The application of the cream to experimental animals, using 36 wistar rats (Rattus norvegicus), treated without cream, smeared with placebo cream, smeared with cream of a mixture of tamarind leaves and turmeric extracts, for 4 weeks all groups of rats received exposure chronic UV-B rays 840 mJ/cm. The results showed that the type of perfume had a significant effect on the dispersion, but HLB and the type of perfume had a significant effect on overall acceptance. HLB 10 cream in all types of perfumes showed the best cream characteristics. The lowest anti-collagenase IC50 value was obtained in the cream with a 5% concentration of turmeric extract and tamarind leaves, IC50 value: 0.36 g/ml. Application of cream mixture of turmeric rhizome extract and tamarind leaves with a concentration of 5% gave a significant effect on the decrease in MMP-1 expression up to 12.147+2.380 μg/ml and increase the amount of collagen by 23. 67% in the skin of wistar rats.