Factors influencing cognitive function in COPD

Objective:Cognitive impairment may frequently be seen in patients with COPD.The goal of this study was to assess relationships clinical parameters and cognition in people with COPD. Methods:We studied 52 patients with stable COPD. Cognitive states were investigated by the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). Age, BMI, the Modified Cumulative Illness Rating Scale(MCIRS), 6-min walk distance, AKG, and PFT were assessed. Results:The rate of cognitive impairment measured by MoCA was 30.8 percent while 25% with the MMSE. MMSE and MoCA scores are associated with 6-min walk distance and comorbidity index in COPD patients. General cognitive function, measured by the MoCA, was negatively correlated with the comorbidity index, while was positively associated with 6-min walk distance in COPD patients,after controlling for possible confounding factors. The none of the COPD severity measures such as pulmonary function tests and arterial blood gases were associated with the risk of cognitive impairment Table 1: Predictor of Cognitive Functions   Cognitive function values with MOCA Cognitive function values with MMSE   beta p value beta p value Age -0.22 0.06 -0.38 0.004 Gender(male) 0.46 0.0001 0.35 0.006 BMI -0.07 0.5 -0.25 0.04 6-min walk distance 0.36 0.002 0.18 0.1 MCIRS -0.32 0.007 -0.12 0.3 FEV1% 0.02 0.8 0.05 0.6 PaO2 0.01 0.9 -0.03 0.7 . Conclusions: Cognitive impairment in patients with COPD is common. COPD patients with better functional capacity and lower comorbidity had a better cognitive functions. MoCA s used in conjunction with the MMSE may provide additional information about the cognitive functions.