A randomized controlled trial on comparison of colon cleansing for colonoscopy bowel preparation using one-day or two-day regimen methods

ABSTRACT Background: Adequate bowel cleansing prior to colonoscopy is important to achieve clearer view of the bowel and ease diagnosis. Objective: This study was performed to compare colon cleansing prior to colonoscopy using one-day and two-day regimens. Method: This study is a randomized controlled clinical trial, the patients were randomly allotted in one-day or two-day colon cleansing groups Polyethylene glycol was used as a laxative agent and colonoscopy was performed either on one-day following the bowel cleansing or non-next day (two-day) after the bowel cleansing. Statistical analysis was performed by SPSS software (version 22). Results: Overall, the two groups had 52 patients and were not significantly different in terms of age and gender. The mean duration of colonoscopy in the one-day group was 9.44 min and in the two-day diet group was 10.5 min, which was also not significantly different, P = 0.098. Total colon cleansing in one-day was acceptable in 94.2% and unacceptable in 5.8% patients. The two-day clearance rate was 80.8% and unacceptable clearance 19.2% patients, which was statistically significant, p = 0.038. Conclusion: The total colon cleansing was better in one-day regime group. The two groups did not different in terms of side effects and these effects were not associated with age and the gender of the patients. Highlights: