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Ruthenium and enzyme-catalyzed dynamic kinetic resolution of alcohols
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Ruthenium acts as a good catalyst for the racemization reaction of secondary alcohols and amines. Ruthenium-catalyzed racemization is coupled with enzymatic kinetic resolution to prepare chiral compounds in 100% theoretical yield. Ten ruthenium complexes (
1
–
10
) act as a good catalyst the for racemization reaction and are also compatible with DKR process. Two other ruthenium complexes [RuCl
2
(PPh
3
)
3
] and [Cp
∗
RuCl(COD)] are active for racemization reaction but their successful compatibility with DKR has not yet been reported. Ru/γ-Al
2
O
3
and Ru–HAP are the heterogeneous catalysts used for the racemization reaction. They have also not been employed for DKR process. Polymer supported ruthenium is employed as a reusable racemization catalyst for aerobic DKR of alcohols.
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Title: Ruthenium and enzyme-catalyzed dynamic kinetic resolution of alcohols
Description:
Ruthenium acts as a good catalyst for the racemization reaction of secondary alcohols and amines.
Ruthenium-catalyzed racemization is coupled with enzymatic kinetic resolution to prepare chiral compounds in 100% theoretical yield.
Ten ruthenium complexes (
1
–
10
) act as a good catalyst the for racemization reaction and are also compatible with DKR process.
Two other ruthenium complexes [RuCl
2
(PPh
3
)
3
] and [Cp
∗
RuCl(COD)] are active for racemization reaction but their successful compatibility with DKR has not yet been reported.
Ru/γ-Al
2
O
3
and Ru–HAP are the heterogeneous catalysts used for the racemization reaction.
They have also not been employed for DKR process.
Polymer supported ruthenium is employed as a reusable racemization catalyst for aerobic DKR of alcohols.
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