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In Vitro Activities of a New Ketolide, ABT-773, against Multidrug-Resistant Gram-Positive Cocci
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ABSTRACT
The in vitro activities of ABT-773 were evaluated against 324 strains of gram-positive bacteria, including multidrug-resistant
Staphylococcus
spp. and
Enterococcus
spp. ABT-773 had lower MIC ranges, MICs at which 50% of isolates are inhibited (MIC
50
s), and MIC
90
s than erythromycin or clindamycin for almost all isolates tested. The MICs of ABT-773 were also lower than those of quinupristin-dalfopristin (Q-D) for methicillin-susceptible
Staphylococcus aureus
,
Rhodococcus
spp., and
Streptococcus
spp., while the MICs of Q-D were lower than those of ABT-773 for methicillin-resistant
S. aureus
and
Enterococcus faecium
, including vancomycin-resistant isolates.
American Society for Microbiology
Title: In Vitro Activities of a New Ketolide, ABT-773, against Multidrug-Resistant Gram-Positive Cocci
Description:
ABSTRACT
The in vitro activities of ABT-773 were evaluated against 324 strains of gram-positive bacteria, including multidrug-resistant
Staphylococcus
spp.
and
Enterococcus
spp.
ABT-773 had lower MIC ranges, MICs at which 50% of isolates are inhibited (MIC
50
s), and MIC
90
s than erythromycin or clindamycin for almost all isolates tested.
The MICs of ABT-773 were also lower than those of quinupristin-dalfopristin (Q-D) for methicillin-susceptible
Staphylococcus aureus
,
Rhodococcus
spp.
, and
Streptococcus
spp.
, while the MICs of Q-D were lower than those of ABT-773 for methicillin-resistant
S.
aureus
and
Enterococcus faecium
, including vancomycin-resistant isolates.
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