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Imbalance of CD4+ lymphocyte subsets in patients with mixed connective tissue disease
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SUMMARYCD4+ (helper/inducer) T lymphocyte subsets were studied in the peripheral blood from patients with mixed connective tissue disease (MCTD) by double-labelling immunofluorescence. The proportion of CD4+CD45RA+ cells was higher (P < 0·01) when compared with controls, whereas CD4+CD29+ cells were markedly diminished (P < 0·001). CD4+CD29+ cells were lower than in patients with progressive systemic sclerosis who were studied in parallel. Upon stimulation with phytohaemagglutinin, CD4+ cells from MCTD patients showed a strong reactivity to acquire the CD29+ phenotype. Expression of high levels of CD29 and other adhesion molecules might lead to facilitated localization of CD4+ cells to inflamed tissue. It is suggested that an increased responsiveness of CD4+ cells to activation signals in vivo and accumulation of CD4+CD29+ cells at tissue sites could result in depletion of this cell subset in the peripheral blood of patients with MCTD.
Oxford University Press (OUP)
Title: Imbalance of CD4+ lymphocyte subsets in patients with mixed connective tissue disease
Description:
SUMMARYCD4+ (helper/inducer) T lymphocyte subsets were studied in the peripheral blood from patients with mixed connective tissue disease (MCTD) by double-labelling immunofluorescence.
The proportion of CD4+CD45RA+ cells was higher (P < 0·01) when compared with controls, whereas CD4+CD29+ cells were markedly diminished (P < 0·001).
CD4+CD29+ cells were lower than in patients with progressive systemic sclerosis who were studied in parallel.
Upon stimulation with phytohaemagglutinin, CD4+ cells from MCTD patients showed a strong reactivity to acquire the CD29+ phenotype.
Expression of high levels of CD29 and other adhesion molecules might lead to facilitated localization of CD4+ cells to inflamed tissue.
It is suggested that an increased responsiveness of CD4+ cells to activation signals in vivo and accumulation of CD4+CD29+ cells at tissue sites could result in depletion of this cell subset in the peripheral blood of patients with MCTD.
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