APOC3-rs2854116 polymorphism related to hypercholesterolemia in primary school children in Hanoi

 Apolipoprotein C3 (APOC3) plays an important role in regulating lipid levels. This study aimed to assess whether the polymorphism APOC3-rs2854116 is associated with lipid profiles in primary school children in Hanoi. A case-control study was designed including 161 cases with dyslipidemia and 406 controls without dyslipidemia. Genotype for APOC3-rs2854116 polymorphism was determined by the polymerase chain reaction and restriction fragment length polymorphism method (PCR-RFLP). The results showed that there were differences in the effect of APOC3-rs2854116 polymorphism to lipid profiles among children with dyslipidemia. In comparison with A/G and A/A carriers, the G/G carriers had the higher concentration of serum TC, TG, and LDL-C (P < 0.05). APOC3-rs2854116 polymorphism was related to hypercholesterolemia in children with the most appropriate genetic model being additive model. Increasing each of the G alleles increased the risk of hypercholesterolemia by 2.2 times (P = 0.005) after adjustment for age and sex. This relationship was almost unchanged after adjustment for obesity-related traits. The study suggested that the APOC3-rs2854116 polymorphism significantly associated with hypercholesterolemia in primary school children in Hanoi independent of obesity-related traits. Keywords APOC3, rs2854116, hypercholesterolemia, primary school children. References [1] A. Kawakami, M. Yoshida, Apolipoprotein CIII links dyslipidemia with atherosclerosis, Journal of atherosclerosis and thrombosis 16(1) (2009) 6-11. https://doi.org/10.5551/jat.e607.[2] D. Gaudet, D. Brisson, K. Tremblay, V.J. Alexander, W. Singleton, S.G. Hughes, J.L. Witztum, Targeting APOC3 in the familial Chylomicronemia syndrome, New England Journal of Medicine 371(23) (2014) 2200-2206. https://doi.org/10.1056/NEJMoa1400284.[3] P. 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