Abstract WP296: Poststroke Dementia is Associated With Early Institutionalization

Objective: To investigate whether poststroke dementia diagnosed after ischemic stroke is associated with earlier permanent institutionalization. Methods: We included 410 consecutive patients aged 55 to 85 years with ischemic stroke admitted to the Helsinki University Central Hospital (The SAM cohort) with a 21-year follow-up. Hospitalization and nursing home admissions were reviewed from national registers. Dementia was diagnosed using the Diagnostic and Statistical Manual of Mental Disorders 3rd edition (DSM-III) criteria. Kaplan-Meier plots log-rank and binary logistic regression (odds ratio, OR) and Cox multivariable proportional hazards model were used to study the association of poststroke dementia status and time of permanent institutionalization. HR and OR with their 95% confidence intervals (CI) are reported. Results: Poststroke dementia was associated with more frequent (OR 2.05; CI 1.29-3.24) permanent institutionalization (Mantel-Haenszel), and earlier permanent institutionalization (5.6 versus 13.6 years; log-rank p<0.001). After adjusting for significant covariates from univariable analyses, poststroke dementia was associated with increased hazards ratio of permanent institutionalization during 21 years of follow-up (1.52; CI 1.05-2.19), see Table. Conclusions: Poststroke dementia at 3 month after stroke is associated with earlier permanent institutionalization compared with stroke patient without poststroke dementia.