Anti-wrinkle efficacy of standardized phenolic acids polymer extract (PAPE) from propolis: implications for anti-aging and skin health

Abstract Background The increasing quest for effective and safe anti-aging skincare solutions has led to a surge in the exploration of natural compounds such as phenolic acids. Despite the proven efficacy of traditional anti-aging ingredients like retinol, their associated side effects have necessitated the search for alternatives. Aims This study aimed to assess the anti-wrinkle efficacy of a standardized phenolic acids polymer extract (PAPE) from propolis, employing both in vitro and clinical methodologies to explore its suitability as a novel anti-aging skincare ingredient for sensitive and non-sensitive skin types. Patients/Methods: The study comprised of evaluating PAPE effects on key skin health biomarkers in dermal fibroblasts and keratinocytes. A double-blind, randomized clinical trial involving female participants aged 30–70 years assessed the wrinkle-reducing effectiveness of face creams formulated with two concentrations of PAPE (1.5% and 3%) over a 28-day period. Results In vitro studies indicated that PAPE could modulate inflammation and tissue remodeling biomarkers. The clinical trial demonstrated that applying PAPE-enriched cream resulted in significant wrinkle reduction, with 25% and 34% improvements for the 1.5% and 3% PAPE formulations, respectively. Subjective feedback from participants further validated the anti-aging efficacy and overall satisfaction with the product. Conclusion Incorporating PAPE offers a compelling anti-aging solution, significantly reducing wrinkle depth with a favorable safety profile. The study substantiates PAPE's potential as an effective and safe alternative to conventional anti-aging ingredients, aligning with the cosmetic industry's shift towards natural, evidence-based formulations.