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The mechanism of anaphase spindle elongation
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AbstractAt anaphase chromosomes move to the spindle poles (anaphase A) and the spindle poles move apart (anaphase B). In vitro studies using isolated diatom spindles demonstrate that the primary mechano‐chemical event responsible for spindle elongation is the sliding apart of half‐spindle microtubules. Further, these forces are generated within the zone of microtubule overlap in the spindle midzone.
Title: The mechanism of anaphase spindle elongation
Description:
AbstractAt anaphase chromosomes move to the spindle poles (anaphase A) and the spindle poles move apart (anaphase B).
In vitro studies using isolated diatom spindles demonstrate that the primary mechano‐chemical event responsible for spindle elongation is the sliding apart of half‐spindle microtubules.
Further, these forces are generated within the zone of microtubule overlap in the spindle midzone.
Related Results
Anaphase B
Anaphase B
Anaphase B spindle elongation is characterized by the sliding apart of overlapping antiparallel interpolar (ip) microtubules (MTs) as the two opposite spindle poles separate, pulli...
Polarity of spindle microtubules in Haemanthus endosperm.
Polarity of spindle microtubules in Haemanthus endosperm.
Structural polarities of mitotic spindle microtubules in the plant Haemanthus katherinae have been studied by lysing endosperm cells in solutions of neurotubulin under conditions t...
Evidence that kinetochore microtubules in crane-fly spermatocytes disassemble during anaphase primarily at the poleward end
Evidence that kinetochore microtubules in crane-fly spermatocytes disassemble during anaphase primarily at the poleward end
ABSTRACT
Anaphase chromosome motion involves the disassembly of kinetochore microtubules. We wished to determine the site of kinetochore microtubule disassembly duri...
Anaphase A: Melting Microtubules Move Chromosomes toward Spindle Poles
Anaphase A: Melting Microtubules Move Chromosomes toward Spindle Poles
The separation of sister chromatids during anaphase is the culmination of mitosis and one of the most strikingly beautiful examples of cellular movement. It consists of two distinc...
Regulation of Mitotic Spindle Disassembly by an Environmental Stress-Sensing Pathway in Budding Yeast
Regulation of Mitotic Spindle Disassembly by an Environmental Stress-Sensing Pathway in Budding Yeast
AbstractTimely spindle disassembly is essential for coordination of mitotic exit with cytokinesis. In the budding yeast Saccharomyces cerevisiae, the microtubule-associated protein...
Role of spindle microtubules in the control of cell cycle timing.
Role of spindle microtubules in the control of cell cycle timing.
Sea urchin eggs are used to investigate the involvement of spindle microtubules in the mechanisms that control the timing of cell cycle events. Eggs are treated for 4 min with Colc...
Regulation of cell cycle by the anaphase spindle midzone
Regulation of cell cycle by the anaphase spindle midzone
Abstract1
Background
A number of proteins accumulate in the spindle midzone and midbody of dividing animal cells. Besides proteins e...
Action of taxol on mitosis: modification of microtubule arrangements and function of the mitotic spindle in Haemanthus endosperm.
Action of taxol on mitosis: modification of microtubule arrangements and function of the mitotic spindle in Haemanthus endosperm.
We have studied the effect of taxol on mitosis in Haemanthus endosperm. Immuno-Gold Stain (IGS), a new immunocytochemical method (17), was used to visualize microtubules (MTs) in t...