Role of acyl-homoserine lactone quorum-sensing system in oral biofilm formation: A review

Background: The function of Acyl homoserine Lactone (AHL) as a communication system in oral biofilm formation by oral microorganisms is essential. A complete understanding of the role of AHL in oral microflora leads to new strategies for controlling biofilms and promoting oral health. The relationship between AHL and oral biofilm formation is not fully understood. Closing this knowledge gap leads to a better understanding of how oral AHL influences the microbiota and enables the development of more effective oral healthcare strategies. Objective: To summarise the connection between AHL and oral biofilm formation, including the mechanisms involved and the impact of Quorum sensing (QS) on oral and dental health. Methods: The authors performed a comprehensive literature review utilising Google Scholar and PubMed to investigate the association between the AHL and the development of biofilms by oral microflora. Result: The research included a comprehensive overview of the existing knowledge regarding the interplay between AHL signalling and the formation of oral biofilms. Conclusion: The AHL quorum sensing system plays a fundamental function in developing and organising oral biofilms, which contribute to oral and dental diseases such as gum disease and dental caries.