Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
“Point” Centromeres of Saccharomyces Harbor Single Centromere-Specific Nucleosomes
View through CrossRef
Abstract
The “point” centromere of budding yeast is genetically defined by an ∼125-bp sequence. Recent fluorescence measurements of kinetochore clusters have suggested that this sequence specifies multiple centromere histone 3 (CenH3) nucleosomes. However, high-resolution mapping demonstrates that there is only one CenH3 nucleosome per centromere, providing biochemical confirmation of the point centromere model.
Title: “Point” Centromeres of Saccharomyces Harbor Single Centromere-Specific Nucleosomes
Description:
Abstract
The “point” centromere of budding yeast is genetically defined by an ∼125-bp sequence.
Recent fluorescence measurements of kinetochore clusters have suggested that this sequence specifies multiple centromere histone 3 (CenH3) nucleosomes.
However, high-resolution mapping demonstrates that there is only one CenH3 nucleosome per centromere, providing biochemical confirmation of the point centromere model.
Related Results
Histone Tail Dynamics in Partially Disassembled Nucleosomes During Chromatin Remodeling
Histone Tail Dynamics in Partially Disassembled Nucleosomes During Chromatin Remodeling
AbstractNucleosomes are structural units of the chromosome consisting of DNA wrapped around histone proteins, and play important roles in compaction and regulation of the chromatin...
Pancentromere landscape and dynamic evolution in Brassica plants
Pancentromere landscape and dynamic evolution in Brassica plants
Abstract
Centromere paradox where functionally conserved centromeres exhibit rapid evolution has long intrigued geneticists and evolutionary biologists. Despite its importa...
The nucleosomes that mark centromere location on chromosomes old and new
The nucleosomes that mark centromere location on chromosomes old and new
Abstract
Proper segregation of chromosomes is an essential component of cell division. The centromere is the locus at which the kinetochore—the proteinaceous complex...
The genetic and epigenetic landscape of the Arabidopsis centromeres
The genetic and epigenetic landscape of the Arabidopsis centromeres
Abstract
Centromeres attach chromosomes to spindle microtubules during cell division and, despite this conserved role, show paradoxically rapid e...
Structural Basis for CAL1-Mediated Centromere Maintenance
Structural Basis for CAL1-Mediated Centromere Maintenance
Summary
Centromeres are microtubule attachment sites on chromosomes defined by the enrichment of CENP-A-containing nucleosomes. To preserve centr...
Structural Basis for Mis18 Complex Assembly: Implications for Centromere Maintenance
Structural Basis for Mis18 Complex Assembly: Implications for Centromere Maintenance
Abstract
The centromere, defined by the enrichment of CENP-A (a Histone H3 variant) containing nucleosomes, is a specialised chromosomal locus that acts as a microt...
Abstract LB034: EWSR1, Ewing sarcoma breakpoint region 1, maintains centromere identity by binding to centromeric R-loops
Abstract LB034: EWSR1, Ewing sarcoma breakpoint region 1, maintains centromere identity by binding to centromeric R-loops
Abstract
The centromere DNA-kinetochore complex is the specialized chromatin structure that mediates chromosome attachment to microtubules and is required for high-f...
CENP-A and CENP-B collaborate to create an open centromeric chromatin state
CENP-A and CENP-B collaborate to create an open centromeric chromatin state
AbstractCentromeres, the sites within chromosomes responsible for accurate genome repartitioning, are epigenetically defined via replacement of canonical histone H3 by the histone ...