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Computational Radical-Scavenging Activity Investigation of Galantamine
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Abstract
Galantamine is a natural alkaloid witha proved antioxidant activity, which easily passes the blood-brain barrier. This makes it a reliable drug for the treatment of many human brain diseases.In this paper we report the results of quantum chemical calculations of the dissociationenthalpies of O-H and C-H bonds in galantamine. The results clearly show the propensity of galantamine to react with radicals in the living organisms.This includes an assessment of the stability of O-H and C-H bonds in it, as well as their acidity.In addition, hydride ion abstraction reactions such as occur with nicotine-amid-adenine-dinucleotide (NAD) are discussed here.
Title: Computational Radical-Scavenging Activity Investigation of Galantamine
Description:
Abstract
Galantamine is a natural alkaloid witha proved antioxidant activity, which easily passes the blood-brain barrier.
This makes it a reliable drug for the treatment of many human brain diseases.
In this paper we report the results of quantum chemical calculations of the dissociationenthalpies of O-H and C-H bonds in galantamine.
The results clearly show the propensity of galantamine to react with radicals in the living organisms.
This includes an assessment of the stability of O-H and C-H bonds in it, as well as their acidity.
In addition, hydride ion abstraction reactions such as occur with nicotine-amid-adenine-dinucleotide (NAD) are discussed here.
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