Determination of Elemental Impurities in Etoricoxib a Non-steroidal Anti-inflammatory Drug by using ICP-MS

Etoricoxib and its genotoxic impurities were identified using a variety of analytical techniques (UV, HPLC, HPTLC etc.) in accordance with previously published studies. The ICP-MS technique was also used to try and identify the heavy metals in other pharmacological compounds. In light of the lack of an analytical method for heavy metal detection in Etoricoxib, this investigation adopted the ICP-MS technique, incorporating a microwave-assisted acid digestion process to analyze eight elemental impurities: Al, Cd, Hg, Ni, As, Pb, V, and Fe.Heavy metals at the following concentrations were successfully detected by the developed analytical method,which demonstrated both sensitivity and speed:10ppm for aluminum, 0.75ppm for mercury, 0.75ppm for arsenic, 0.25ppm for lead, 0.25ppm for cadmium, 10ppm for iron, 10ppm for nickel, and 5.00ppm for vanadium. Additionally, it showed that it could measure these elemental impurities at concentrations as high as 200percent of the limit. The analytical technique revealed a linear relationship, supported by a correlation coefficient that surpassed 0.99. Recovery rates for heavy metals at three distinct concentrations, after the introduction of Etoricoxib samples, were determined to be within the acceptable limits of 70% to 150%. In terms of precision, the actual percentage RSD is less than 2%. Since ICP-MS heavy metal analysis is an effective technique, the suggested approach can be used to routinely quantitatively determine the eight elemental impurities in Etoricoxib.