Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Alphaherpesviral US3 Kinase Induces Cofilin Dephosphorylation To Reorganize the Actin Cytoskeleton
View through CrossRef
ABSTRACTThe conserved alphaherpesviral serine/threonine kinase US3 causes dramatic actin rearrangements, associated with increased viral spread. Here, we show that US3 of pseudorabies virus (PRV) leads to activation (dephosphorylation) of the central actin regulator cofilin. A mutation that impairs US3 kinase activity and the group I p21-activated kinase inhibitor IPA-3 inhibited US3-mediated cofilin activation. Additionally, expression of phosphomimetic S3D cofilin significantly suppressed the ability of US3 to cause cell projections and cell rounding. In conclusion, the US3 kinase of PRV leads to activation (dephosphorylation) of cofilin, and cofilin contributes to US3-mediated actin rearrangements.
American Society for Microbiology
Title: Alphaherpesviral US3 Kinase Induces Cofilin Dephosphorylation To Reorganize the Actin Cytoskeleton
Description:
ABSTRACTThe conserved alphaherpesviral serine/threonine kinase US3 causes dramatic actin rearrangements, associated with increased viral spread.
Here, we show that US3 of pseudorabies virus (PRV) leads to activation (dephosphorylation) of the central actin regulator cofilin.
A mutation that impairs US3 kinase activity and the group I p21-activated kinase inhibitor IPA-3 inhibited US3-mediated cofilin activation.
Additionally, expression of phosphomimetic S3D cofilin significantly suppressed the ability of US3 to cause cell projections and cell rounding.
In conclusion, the US3 kinase of PRV leads to activation (dephosphorylation) of cofilin, and cofilin contributes to US3-mediated actin rearrangements.
Related Results
Cofilin-1 – Induced Actin Reorganization and Phosphatidylserine Exposure in Platelets
Cofilin-1 – Induced Actin Reorganization and Phosphatidylserine Exposure in Platelets
Abstract
Background: Platelet activation leads to the transbilayer movement of phosphatidylserine (PS) from inner to the outer leaflet of membrane bilayer. Exteriori...
Cofilin Signaling in the CNS Physiology and Neurodegeneration
Cofilin Signaling in the CNS Physiology and Neurodegeneration
All eukaryotic cells are composed of the cytoskeleton, which plays crucial roles in coordinating diverse cellular functions such as cell division, morphology, migration, macromolec...
Synaptotoxicity in Alzheimer's Disease Involved a Dysregulation of Actin Cytoskeleton Dynamics through Cofilin 1 Phosphorylation
Synaptotoxicity in Alzheimer's Disease Involved a Dysregulation of Actin Cytoskeleton Dynamics through Cofilin 1 Phosphorylation
Amyloid-β (Aβ) drives the synaptic impairment and dendritic spine loss characteristic of Alzheimer's disease (AD), but how Aβ affects the actin cytoskeleton remains unknown and con...
14-3-3 Negatively Regulates Actin Filament Formation in the Deep Branching EukaryoteGiardia lamblia
14-3-3 Negatively Regulates Actin Filament Formation in the Deep Branching EukaryoteGiardia lamblia
AbstractThe phosphoserine/phosphothreonine-binding protein 14-3-3 is known to regulate actin, this function has been previously attributed to sequestration of phosphorylated cofili...
Deciphering the actin structure-dependent preferential cooperative binding of cofilin
Deciphering the actin structure-dependent preferential cooperative binding of cofilin
Abstract
The mechanism underlying the preferential and cooperative binding of cofilin and the expansion of clusters toward the pointed-end side of actin filaments r...
Deciphering the actin structure-dependent preferential cooperative binding of cofilin
Deciphering the actin structure-dependent preferential cooperative binding of cofilin
Abstract
The mechanism underlying the preferential and cooperative binding of cofilin and the expansion of clusters toward the pointed-end side of actin filaments r...
Cofilin promotes actin turnover and flexibility to drive coordinated cell movements
in vivo
Cofilin promotes actin turnover and flexibility to drive coordinated cell movements
in vivo
Abstract
Embryos display a striking ability to repair wounds rapidly, with no inflammation or scarring. Embryonic wound healing is driven by the ...
Cofilin(s) and Mitochondria: Function Beyond Actin Dynamics
Cofilin(s) and Mitochondria: Function Beyond Actin Dynamics
ADF/cofilins form a family of small, widely expressed actin-binding proteins, regulating actin dynamics in various cellular and physiological processes in all eukaryotes from yeast...