Multienzyme Complex in Fatty Acid Biosynthesis

Fatty acid biosynthesis is a fundamental process that occurs in all living organisms and involves multiple reaction steps. Thus, a systematic transfer of the intermediates between the different catalytic sites is highly required for the efficient regulation of a pathway as well as for sustaining growth. Multienzyme complex, a protein complex that comprises a group of interacting enzymes in a specific metabolic pathway, has been identified to catalyze numerous metabolic pathways, including fatty acid synthesis. The existence of a lipogenic multienzyme complex that involves protein interaction between numerous enzymes that took part in fatty acid biosynthesis plays a key fundamental role in channelling the intermediate substrates. Herein, the growing evidence for the formation of multienzyme complexes in fatty acid synthesis and the properties of the complex will be elucidated in this chapter.