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Computational Analysis of Single Nucleotide polymorphisms (SNPs) in Human TCell Acute Lymphocytic Leukemia Protein 1 (TAL1) Gene/Comprehensive Study
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Abstract
Background
TAL1
is a proto-oncogene whose distorted modifications in committed T-cell Precursors is related with the development of T-ALL, it also found to be related to many other human hematological diseases such as lymphoblastic lymphoma, immunodeficiency 18, acute myeloid leukemia and diamond-blackfan Anemia.
Objectives
This study aims to predict the effect of nsSNPs on
TAL1
protein structure function
Methods
Retrieved nSNPs in the coding and
3’UTR
regions were analyzed using different in silico tools. Interactions of
TAL1
with functionally similar genes were investigated using Genemania. Post-translational modifications in several sites of the protein were also investigated.
Results
Out of ninety nsSNPs identified, only eight were found damaging to protein function of which one is located in the basis helix-loop-helix domain (bHLH). Two SNPs were anticipated by PolymiRTs to prompt disturbance or creation of miR binding sites.
Conclusion
The present study is the first ever computational analysis of
TAL1
’s nsSNPs hence this effort might be of help in the near future for inventing early diagnostic and therapeutic measures for T-ALL
Title: Computational Analysis of Single Nucleotide polymorphisms (SNPs) in Human TCell Acute Lymphocytic Leukemia Protein 1 (TAL1) Gene/Comprehensive Study
Description:
Abstract
Background
TAL1
is a proto-oncogene whose distorted modifications in committed T-cell Precursors is related with the development of T-ALL, it also found to be related to many other human hematological diseases such as lymphoblastic lymphoma, immunodeficiency 18, acute myeloid leukemia and diamond-blackfan Anemia.
Objectives
This study aims to predict the effect of nsSNPs on
TAL1
protein structure function
Methods
Retrieved nSNPs in the coding and
3’UTR
regions were analyzed using different in silico tools.
Interactions of
TAL1
with functionally similar genes were investigated using Genemania.
Post-translational modifications in several sites of the protein were also investigated.
Results
Out of ninety nsSNPs identified, only eight were found damaging to protein function of which one is located in the basis helix-loop-helix domain (bHLH).
Two SNPs were anticipated by PolymiRTs to prompt disturbance or creation of miR binding sites.
Conclusion
The present study is the first ever computational analysis of
TAL1
’s nsSNPs hence this effort might be of help in the near future for inventing early diagnostic and therapeutic measures for T-ALL.
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