Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
HEPATOTOXICITY;
View through CrossRef
Objectives: To evaluate the protective role of silymarin against methotrexate(MTX) induced hepatotoxicity in mice. Study design: Randomized controlled trial on animalmodel. Period: 06 months from March 2016 to August 2016. Settings: Department ofPharmacology and Therapeutics, Army Medical College, Rawalpindi. Material and Methods:Thirty male BALB/c mice were randomly divided into five groups (n=6). Group A received 0.2 mlnormal saline intraperitoneally served as control for MTX. Group B received 0.2 ml distilled waterorally for 7 days served as control for oral silymarin. Group C received single intraperitonealinjection of MTX 20 mg/kg. Group D received silymarin 25 mg/kg orally for seven days. GroupE received silymarin 25 mg/kg orally for 7 days with MTX 20 mg/kg intraperitoneally at day 4.Blood samples for measuring serum ALT (Alanine Transaminase), AST (Aspartate transaminase)and ALP (Alkaline Phosphatase) along with liver samples for hepatic histological examinationwere taken after 24 hours of last dose. Results: Silymarin show hepatoprotective effect againstMTX induced hepatotoxicity. Conclusion: Silymarin has hepatoprotective potential whenadministered along with MTX.
Independent Medical Trust
Title: HEPATOTOXICITY;
Description:
Objectives: To evaluate the protective role of silymarin against methotrexate(MTX) induced hepatotoxicity in mice.
Study design: Randomized controlled trial on animalmodel.
Period: 06 months from March 2016 to August 2016.
Settings: Department ofPharmacology and Therapeutics, Army Medical College, Rawalpindi.
Material and Methods:Thirty male BALB/c mice were randomly divided into five groups (n=6).
Group A received 0.
2 mlnormal saline intraperitoneally served as control for MTX.
Group B received 0.
2 ml distilled waterorally for 7 days served as control for oral silymarin.
Group C received single intraperitonealinjection of MTX 20 mg/kg.
Group D received silymarin 25 mg/kg orally for seven days.
GroupE received silymarin 25 mg/kg orally for 7 days with MTX 20 mg/kg intraperitoneally at day 4.
Blood samples for measuring serum ALT (Alanine Transaminase), AST (Aspartate transaminase)and ALP (Alkaline Phosphatase) along with liver samples for hepatic histological examinationwere taken after 24 hours of last dose.
Results: Silymarin show hepatoprotective effect againstMTX induced hepatotoxicity.
Conclusion: Silymarin has hepatoprotective potential whenadministered along with MTX.
Related Results
Case Reports on Severe Antituberculosis-Drug Induced Hepatotoxicity in Tuberculosis Patients: The Post-Incidence Therapy
Case Reports on Severe Antituberculosis-Drug Induced Hepatotoxicity in Tuberculosis Patients: The Post-Incidence Therapy
Introduction: The first-line regimen for tuberculosis (TB) treatment comprises Isoniazid, Rifampicin, Pyrazinamide, and Ethambutol. However, these drugs are known to potentially c...
Hepatotoxicity of antiretroviral drugs in HIV HCV patients with congenital coagulopathies followed at an Haemophilia Unit during a decade
Hepatotoxicity of antiretroviral drugs in HIV HCV patients with congenital coagulopathies followed at an Haemophilia Unit during a decade
Summary. The aim of the study was to assess the incidence and the cumulative probability of cytolytic and cholestatic hepatotoxicity during antiretroviral treatment in a group of ...
Prevalence of hepatotoxicity among HIV-infected patients in Ethiopia: a systematic review and meta-analysis
Prevalence of hepatotoxicity among HIV-infected patients in Ethiopia: a systematic review and meta-analysis
AbstractBackgroundGlobally, the human immunodeficiency virus has been recognized as a major public health concern. The direct toxicity of antiretroviral medicines or their active m...
Predictors of severe hepatotoxicity among retroviral infected adults on HAART regimen in Ilubabor Zone, Southwest Ethiopia
Predictors of severe hepatotoxicity among retroviral infected adults on HAART regimen in Ilubabor Zone, Southwest Ethiopia
AbstractNearly half of the deaths among hospitalized human immuno deficiency virus-infected patients in the highly active antiretroviral therapy era have been attributed to liver d...
Acute Ethanol Coingestion Confers a Lower Risk of Hepatotoxicity after Deliberate Acetaminophen Overdose
Acute Ethanol Coingestion Confers a Lower Risk of Hepatotoxicity after Deliberate Acetaminophen Overdose
AbstractObjectives: Little is known about the clinical significance of acute ethanol coingestion around the time of acetaminophen (paracetamol) overdose. This study prospectively ...
Understanding and using Animal Models of Hepatotoxicity
Understanding and using Animal Models of Hepatotoxicity
Hepatotoxicity is a critical health hazard, primarily contributing to the increased incidence of deaths
globally. The liver is one of the major and extremely vital organs of the hu...
Inflammatory bowel disease and drug-induced liver damage
Inflammatory bowel disease and drug-induced liver damage
The article presents the results of a review of publications devoted to the study of the problems of drug-induced liver damage in inflammatory bowel diseases (IBD). The hepatotoxic...
Network Toxicology and Molecular Docking Analysis of Antituberculosis Drug‐Induced Hepatotoxicity
Network Toxicology and Molecular Docking Analysis of Antituberculosis Drug‐Induced Hepatotoxicity
ABSTRACT
Drug‐induced hepatotoxicity (DIH) is a serious adverse effect of Antituberculosis (anti‐TB) therapy, frequently causing treatment interruption and poor o...