Synthesis, Characterization and Antifungal Activity of Metal Chelates Based on 8-Hydroxyquinoline and Metronidazole

In the present study, 5-chloromethyl-8-hydroxyquinoline (CMQ) hydrochloride, a versatile derivative of 8-hydroxyquinoline is reacted with a potent antibiotic drug metronidazole in order to yield a novel ligand namely 5-((2-(2-methyl-5-nitro-1H-imidazol-1-yl) ethoxy) methyl)-8-hydroxyquinoline (NIHQ). The co-ordinate metal chelates of the ligand NIHQ were prepared using divalent metal ions viz., Cu2+, Co2+, Ni2+, Mn2+, Zn2+ and Cd2+ by simple method. The ligand NIHQ and its all metal chelates were duly characterized for elemental content, spectral features, M: L (metal: ligand) ratio, and magnetic moment. The results of electronic spectral studies and magnetic properties indicated octahedral geometry for all the metal chelates. Antifungal activity of all the samples was tested against plant pathogens such as Aspergillus niger, Botrydepladia thiobromine, Nigrospora Sp., and Fusarium oxyporium. The results showed promising antifungal activity of all the metal chelates.