Effects of Moringa oleifera Extract on Burn Wound Healing in Mice

Background: Burn injuries are a significant public health concern in Indonesia, with a high mortality rate and complications arising from severe burns. This study aimed to evaluate the efficacy of Moringa oleifera extract in promoting burn wound healing in mice, comparing its effects at concentrations of 10.00% and 15.00% with a standard treatment, Bioplacenton. Methods: A laboratory experimental design was employed using male mice (Mus musculus) divided into four treatment groups: negative control (no treatment), positive control (Bioplacenton), and two groups treated with 10.00% and 15.00% Moringa oleifera extract. The healing process was monitored over 14 days, with wound diameter measurements taken on days 1, 7, and 14. Statistical analyses, including the Kruskal-Wallis test and Mann-Whitney test, were conducted to assess differences in wound size and healing time among the groups. Result: Statistically significant differences in burn wound size were observed in the treatment groups (p = 0.006). Both concentrations of Moringa oleifera extract (10.00% and 15.00%) demonstrated statistically significant wound size reduction compared to the negative control (p = 0.002), similar to Bioplacenton (p = 0.041). The 15.00% Moringa oleifera extract showed the best results in reducing burn wound size and accelerating healing time, with a statistically significant difference compared to the negative control (p = 0.009) and comparable efficacy to Bioplacenton (p = 0.310). The healing time for the 10.00% extract did not show statistically significant differences compared to the negative control (p = 0.065). Conclusion: The study concludes that Moringa oleifera extract, particularly at a concentration of 15.00%, is effective in promoting burn healing, reducing wound size, and accelerating healing time. This extract presents a promising natural alternative for burn wound treatment, with potential applications in clinical settings. Future research should explore various concentrations and include histopathological analyses to further elucidate the mechanisms of action.