Mutation in MERS-CoV

The Middle East respiratory syndrome (MERS-CoV) is a betacoronavirusborne acute viral illness. Since it first appeared in 2012, multiple cases of animal-t- -human transmission of MERS-CoV have been observed, indicating that MERS-CoV has the potential to cause a widespread epidemic. It has been detected in bronchial samples from more than 27 countries, with approximately 2,505 reported cases and a mortality rate of 36%. Genetic heterogeneity of MERS-CoV between different samples may have paved the way for cross-species transmission and changes in the tropics between species and within species. MERS-CoV has many evolutionary genomic origins in spike protein, envelope protein, matrix, and non-structural proteins (nsps) and mutates continuously. In this chapter, we highlighted the causes and significance of mutation in the amino acid sequences of spike protein, envelop protein, matrix protein, nucleocapsid protein, and snp. Among the most enduring obstacles in controlling coronavirus disease is the evolution of the virus, which is influenced by genetic diversity, mutation, and natural selection.