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Room temperature Palladium-Catalyzed C─H Functionalization of Benzothiazole with Iodo(Hetero)Arenes
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A versatile synthetic protocol involving the
room temperature direct arylation of benzothiazole with a wide variety of
iodo(hetero)arenes under palladium-catalyzed conditions and promoted by HFIP as
the reaction solvent has been presented herewith. An in-situ one-pot sequential
HFIP promoted selective iodination of (hetero)arenes followed by Pd-catalyzed
direct arylation of benzothiazole has also been disclosed. Synthesis of PMX 610 (antitumor agent) analog has been disclosed and also CJM 126 (antitumor agent) has been synthesized.
Title: Room temperature Palladium-Catalyzed C─H Functionalization of Benzothiazole with Iodo(Hetero)Arenes
Description:
A versatile synthetic protocol involving the
room temperature direct arylation of benzothiazole with a wide variety of
iodo(hetero)arenes under palladium-catalyzed conditions and promoted by HFIP as
the reaction solvent has been presented herewith.
An in-situ one-pot sequential
HFIP promoted selective iodination of (hetero)arenes followed by Pd-catalyzed
direct arylation of benzothiazole has also been disclosed.
Synthesis of PMX 610 (antitumor agent) analog has been disclosed and also CJM 126 (antitumor agent) has been synthesized.
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