EVALUATION OF PRESEPSIN, PROCALCITONIN AND C REACTIVE PROTEIN IN EARLY DETECTION OF SEPSIS

Sepsis is a life-threatening condition that arises when the host responds to an infection and damages its organs. It is often difcult to distinguish between bacterial and non-bacterial aetiologies early in suspected sepsis. Clinical signs of sepsis such as tachycardia, leucocytosis, tachypnea, and pyrexia, often overlap with other non-infectious conditions in critically ill patients. Concurrently, it has been shown that prompt diagnosis and early administration of appropriate antibiotic therapy considerably improve the outcomes of septic patients. The present work is based on the observations made in 110 patients of sepsis admitted in Surgery, medicine, paediatrics wards Of Nehru Hospital of B.R.D. Medical College, Gorakhpur during the period of one year from May 2023 to April 2024. A complete sepsis panel which includes CRP, complete blood cell counts (CBC), procalcitonin, and presepsin, was assayed for each of the enrolled patients along with thorough history taking and general examination.In summary, all three biomarkers—CRP, PCT, and Presepsin show signicant differences in levels between septic and non-septic patients. CRP and Presepsin exhibit highly signicant differences with p-values less than 0.0001, while PCT shows a signicant difference with a p-value of 0.0171. These results underscore the potential utility of these biomarkers in distinguishing between septic and non-septic conditions. Presepsin has excellent discriminatory ability in distinguishing between septic and non-septic patients. The high AUC value close to 1.0 signies that Presepsin is a highly accurate biomarker for diagnosing sepsis. In conclusion, in patients with suspected sepsis, presepsin and PCT showed a good diagnostic accuracy superior to CRP and PCT. In given conditions, presepsin is better than CRP and PCT for early diagnosis of sepsis.