Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Melatonin and Melatonin Agonist for Delirium in the Elderly Patients
View through CrossRef
The objective of this review is to summarize the available data on the use of melatonin and melatonin agonist for the prevention and management of delirium in the elderly patients from randomized controlled trials (RCTs). A systematic search of 5 major databases PubMed, MEDLINE, PsychINFO, Embase, and Cochrane Library was conducted. This search yielded a total of 2 RCTs for melatonin. One study compared melatonin to midazolam, clonidine, and control groups for the prevention and management of delirium in individuals who were pre- and posthip post-hip arthroplasty. The other study compared melatonin to placebo for the prevention of delirium in older adults admitted to an inpatient internal medicine service. Data from these 2 studies indicate that melatonin may have some benefit in the prevention and management of delirium in older adults. However, there is no evidence that melatonin reduces the severity of delirium or has any effect on behaviors or functions in these individuals. Melatonin was well tolerated in these 2 studies. The search for a melatonin agonist for delirium in the elderly patients yielded 1 study of ramelteon. In this study, ramelteon was found to be beneficial in preventing delirium in medically ill individuals when compared to placebo. Ramelteon was well tolerated in this study.
Title: Melatonin and Melatonin Agonist for Delirium in the Elderly Patients
Description:
The objective of this review is to summarize the available data on the use of melatonin and melatonin agonist for the prevention and management of delirium in the elderly patients from randomized controlled trials (RCTs).
A systematic search of 5 major databases PubMed, MEDLINE, PsychINFO, Embase, and Cochrane Library was conducted.
This search yielded a total of 2 RCTs for melatonin.
One study compared melatonin to midazolam, clonidine, and control groups for the prevention and management of delirium in individuals who were pre- and posthip post-hip arthroplasty.
The other study compared melatonin to placebo for the prevention of delirium in older adults admitted to an inpatient internal medicine service.
Data from these 2 studies indicate that melatonin may have some benefit in the prevention and management of delirium in older adults.
However, there is no evidence that melatonin reduces the severity of delirium or has any effect on behaviors or functions in these individuals.
Melatonin was well tolerated in these 2 studies.
The search for a melatonin agonist for delirium in the elderly patients yielded 1 study of ramelteon.
In this study, ramelteon was found to be beneficial in preventing delirium in medically ill individuals when compared to placebo.
Ramelteon was well tolerated in this study.
Related Results
Delirium: characteristics and monitoring
Delirium: characteristics and monitoring
This thesis starts by sharpening the diagnosis of delirium and proposing a new reference in Chapter 2 titled: The Delirium Interview. Composed after in-depth discussions with delir...
ICU delirium:what is different between the type of diseases?
ICU delirium:what is different between the type of diseases?
Abstract
Background: Delirium is an acute neurological disorder that is quite common complication in intensive care unit (ICU) patients. However, there are no studies to fo...
Melatonin Biosynthesis, Receptors, and the Microbiota–Tryptophan–Melatonin Axis: A Shared Dysbiosis Signature Across Cardiac Arrhythmias, Epilepsy, Malignant Proliferation, and Cognitive Trajectories
Melatonin Biosynthesis, Receptors, and the Microbiota–Tryptophan–Melatonin Axis: A Shared Dysbiosis Signature Across Cardiac Arrhythmias, Epilepsy, Malignant Proliferation, and Cognitive Trajectories
Melatonin, an indolic neuromodulator with putative oncostatic and proposed anti-inflammatory properties, primarily demonstrated in preclinical models, is produced at extrapineal si...
Effects of administration of melatonin on prevalence of delirium and duration of stay in patients admitted to neurosurgical intensive care unit – A prospective study
Effects of administration of melatonin on prevalence of delirium and duration of stay in patients admitted to neurosurgical intensive care unit – A prospective study
Background: The occurrence of delirium in patients who undergo elective surgeries is a common occurrence. Multiple studies have assessed the effect of different drugs in various el...
Rivastigmine patch (Exelon patch) compared to melatonin patch in prevention of postoperative delirium in the elderly
Rivastigmine patch (Exelon patch) compared to melatonin patch in prevention of postoperative delirium in the elderly
Abstract
Background
Postoperative delirium (PD) is an acute, transient disorder of consciousness, attention, perception, and cognition. Many theories, such as decreased cholinergic...
Delirium In The Emergency Department: Diagnosis, Evaluation, And Management
Delirium In The Emergency Department: Diagnosis, Evaluation, And Management
Delirium, an acute confusional state characterized by disturbances in attention, cognition, and arousal, is present in 7 to 10% of older emergency department (ED) patients, underdi...
Melatonin and mammary cancer: a short review.
Melatonin and mammary cancer: a short review.
Melatonin is an indolic hormone produced mainly by the pineal gland. The former hypothesis of its possible role in mammary cancer development was based on the evidence that melaton...
Competing influences of mental stress and melatonin on skin temperature regulation
Competing influences of mental stress and melatonin on skin temperature regulation
Introduction: In preparation for sleep, endogenous melatonin release increases distal skin temperature due to elevated skin blood flow, which contributes to reductions in core body...