Specifics of Evoked Cognitive Potentials P300 in Chronic Brain Ischemia

Significant differences were identified during this study in ECP values of patients with chronic cerebral ischemia compared to normal age range. Change of evoked cognitive potentials was observed in healthy individuals as evidenced by change of maximum amplitude of cognitive potentials in frontal lead in simple tests and normalization of topographic distribution of evoked cognitive potentials upon increased level of challenge of cognitive task. Use of P300 method for measuring evoked cognitive potentials allowed identifying significant changes in electric activity of brain in patients with chronic cerebral ischemia and mild cognitive impairment of various natures. Although, these changes were qualitatively similar, changes in evoked cognitive potentials in patients with mild cognitive impairment disorders of varying nature had quantitative differences upon use of tests measuring various modality and level of difficulty of cognitive task.