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Role of Immune Cells in Mediating the Causal Effect of Gut Microbiota on Type 2 Diabetes
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Background:
Previous studies have suggested that gut microbiota and
immune system regulation have potential links with type 2 diabetes (T2D). However,
the causal association between gut microbiota and T2D and whether immune cells
mediate this interaction is unclear.
Methods:
A two-sample, two-step Mendelian randomization (MR) study utilizing an
initial inverse-variance weighted (IVW) method was performed to explore the causal
impact of gut microbiota on T2D and the intermediary role of immune cells.
Results:
The MR analysis assigned 4 gut microbiota and metabolic pathways that
increase the risk of T2D (G_Prevotella, g_Anaerotruncus, g_Streptococcus.s_
Streptococcus_parasanguinis, and the pathway of PANTO-PWY) and 4 other gut
microbiota and metabolic pathways that have a protective effect against T2D (PWY5667, PWY-6892, PWY-7221, and the bacterial g_Paraprevotella.s_Paraprevotella_
clara). Furthermore, 17 immune cell traits have been identified as associated with T2D.
The finding from mediation MR analysis revealed that PANTO-PWY increases T2D
risk via CD3 on HLA DR+ CD4+, whereas PWY-7221 reduces T2D risk through CD4
on CD4 Treg.
Conclusion:
The research reveals a mediated causal link between the gut microbiota
and T2D via immune cells.
Bentham Science Publishers Ltd.
Title: Role of Immune Cells in Mediating the Causal Effect of Gut Microbiota on Type 2 Diabetes
Description:
Background:
Previous studies have suggested that gut microbiota and
immune system regulation have potential links with type 2 diabetes (T2D).
However,
the causal association between gut microbiota and T2D and whether immune cells
mediate this interaction is unclear.
Methods:
A two-sample, two-step Mendelian randomization (MR) study utilizing an
initial inverse-variance weighted (IVW) method was performed to explore the causal
impact of gut microbiota on T2D and the intermediary role of immune cells.
Results:
The MR analysis assigned 4 gut microbiota and metabolic pathways that
increase the risk of T2D (G_Prevotella, g_Anaerotruncus, g_Streptococcus.
s_
Streptococcus_parasanguinis, and the pathway of PANTO-PWY) and 4 other gut
microbiota and metabolic pathways that have a protective effect against T2D (PWY5667, PWY-6892, PWY-7221, and the bacterial g_Paraprevotella.
s_Paraprevotella_
clara).
Furthermore, 17 immune cell traits have been identified as associated with T2D.
The finding from mediation MR analysis revealed that PANTO-PWY increases T2D
risk via CD3 on HLA DR+ CD4+, whereas PWY-7221 reduces T2D risk through CD4
on CD4 Treg.
Conclusion:
The research reveals a mediated causal link between the gut microbiota
and T2D via immune cells.
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