<b>Profiling of Macrovascular and Microvascular Complications in Young-Onset Type 2 Diabetes: A Scoping Review</b>

<p dir="ltr">Young-onset type 2 diabetes is defined as type 2 diabetes diagnosed before the age of 40 years. It is characterized by more aggressive pathology compared with type 2 diabetes diagnosed later in life, leading to earlier susceptibility to macrovascular and microvascular complications. This scoping review comprehensively profiles the complications associated with young-onset type 2 diabetes. Early detection of these complications, comprehensive risk assessment, and multifaceted glycemic management will improve quality of life and overall life expectancy in this population.</p><p><br></p><p dir="ltr"><b>Key Points</b></p><p dir="ltr">· This review identified and synthesized evidence on microvascular and macrovascular complications related to young-onset type 2 diabetes.</p><p dir="ltr">· Findings revealed that cardiovascular conditions are the most common macrovascular complications, and diabetic nephropathy and retinopathy are the most common microvascular complications of young-onset type 2 diabetes.</p><p dir="ltr">· Decline in β-cell function is accelerated in this population compared with people with later-onset type 2 diabetes or type 1 diabetes; hence, early screening, interventions to improve β-cell function, and effective glycemic management are particular important.</p>