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Ketene‐S,N‐acetals as synthons for heterocycles New Synthesis of Pyrimidinones
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AbstractKetene‐S,N‐acetals of type 1, 2 reacted with isocyanates to 5‐cyano‐uracils 3 and 5‐cyano‐pyrimidin‐2‐ones 4, 5. Reaction of these with N nucleophiles was investigated furnishing 6‐amino‐pyrimidinones 6 as well as condensed pyrimidin‐2‐ones 7‐‐10 and 13. Cyanic acid esters gave 5‐cyano‐pyrimidin‐4‐ones 16. Behavior of 16 toward nucleophiles is reported.
Title: Ketene‐S,N‐acetals as synthons for heterocycles New Synthesis of Pyrimidinones
Description:
AbstractKetene‐S,N‐acetals of type 1, 2 reacted with isocyanates to 5‐cyano‐uracils 3 and 5‐cyano‐pyrimidin‐2‐ones 4, 5.
Reaction of these with N nucleophiles was investigated furnishing 6‐amino‐pyrimidinones 6 as well as condensed pyrimidin‐2‐ones 7‐‐10 and 13.
Cyanic acid esters gave 5‐cyano‐pyrimidin‐4‐ones 16.
Behavior of 16 toward nucleophiles is reported.
Related Results
ChemInform Abstract: Ketene‐S,N‐acetals as Synthons for Heterocycles. New Synthesis of Pyrimidinones.
ChemInform Abstract: Ketene‐S,N‐acetals as Synthons for Heterocycles. New Synthesis of Pyrimidinones.
AbstractThe reactions of the ketene‐N,S‐acetals (I) and (IV) with the isocyanates (II) and the cyanates (XVIII) are investigated, giving the products shown in the scheme....
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