Potential drug–drug interactions in children with acute lymphoblastic leukaemia: a cohort study

Objective: To evaluate the potential drug interactions in patients with acute lymphoblastic leukaemia in the remission induction period of treatment. Design: A prospective cohort study. Setting: A tertiary referral centre. Subjects: Twenty-two children undergoing treatment for acute lymphoblastic leukaemia. The median age was 4.5 years (minimum of 1 and maximum of 18 years) with male predominance (54.4%). Main outcome measure: Presence of potential drug interactions in patients undergoing treatment for precursor cell lymphoblastic  leukaemialymphoma. The potential drug interactions term refers to the ability of a drug to affect the pharmacologic intensityas well as the therapeutic effect of another and cause adverse reactions, as well as the possibility of clinical manifestations. Results: All participants were exposed to at least one potential drug interaction. About 60% of interactions classified as more severe. Every new drug included in the treatment increased the chance of potential drug-drug interactions by 0.4 times. Conclusion: These results demonstrated the patients under chemotherapeutic care for lymphoblastic leukaemia-lymphoma have high potential for drug interactions of greater severity.