Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Heparin - Pluronic F127 nanogel with optimal component ratio for drug delivery applications
View through CrossRef
This study aimed to synthesize a nanogel system based copolymers of Heparin (Hep) and Pluronic F127 (F127) with optimal Hep:F127 ratio for delivering poor water soluble drug and Platinum-based drugss. Firstly, Hep-F127 conjugates were formed via disulfide bridges of cystamine molecules. The obtained Hep-F127 systems were then proved and characterized using Proton nuclear magnetic resonance (1H-NMR), Dynamic Light Scattering (DLS)) methods. Cisplatin (CPT) was used as the Pt drug model, meanwhile Paclitaxel (PTX) was used as poor water-soluble drug model. The encapsulation ability for CPT and PTX was investigated and compared to choose the optimal Hep-F127 ratio. This Hep-F127 nanogel system is expected to be a good carrier for delivering drugs with different properties.
Academy of Military Science and Technology
Title: Heparin - Pluronic F127 nanogel with optimal component ratio for drug delivery applications
Description:
This study aimed to synthesize a nanogel system based copolymers of Heparin (Hep) and Pluronic F127 (F127) with optimal Hep:F127 ratio for delivering poor water soluble drug and Platinum-based drugss.
Firstly, Hep-F127 conjugates were formed via disulfide bridges of cystamine molecules.
The obtained Hep-F127 systems were then proved and characterized using Proton nuclear magnetic resonance (1H-NMR), Dynamic Light Scattering (DLS)) methods.
Cisplatin (CPT) was used as the Pt drug model, meanwhile Paclitaxel (PTX) was used as poor water-soluble drug model.
The encapsulation ability for CPT and PTX was investigated and compared to choose the optimal Hep-F127 ratio.
This Hep-F127 nanogel system is expected to be a good carrier for delivering drugs with different properties.
Related Results
Case Report: Maggots' Infestation As a Predisposing Condition for Heparin-Induced Thrombocytopenia, a Newest Entity
Case Report: Maggots' Infestation As a Predisposing Condition for Heparin-Induced Thrombocytopenia, a Newest Entity
Abstract
Introduction
Thromobocytopenia is a well-recognized complication of heparin with risk of venous or arterial thrombosis. Heparin induced throm...
HEPARIN STIMULATES FIBROBLAST GROWTH INDUCED BY PDGF
HEPARIN STIMULATES FIBROBLAST GROWTH INDUCED BY PDGF
Heparin binds to smooth muscle cells and endothelial cells. It inhibits the proliferation of the smooth muscle cells and modulates the growth of endothelial cells. Fibroblasts whic...
Disulfide-crosslinked heparin-pluronic nanogels as a redox-sensitive nanocarrier for intracellular protein delivery
Disulfide-crosslinked heparin-pluronic nanogels as a redox-sensitive nanocarrier for intracellular protein delivery
Improving the efficacy of drug delivery via nanocarriers has been a major issue in the field of intravenous delivery. In this study, a polymeric nanogel was developed to enhance th...
Pembuatan Nanogel Alginat beserta Uji Evaluasi
Pembuatan Nanogel Alginat beserta Uji Evaluasi
Abstract. Nanogels are drug delivery systems based on hydrogels that possess nanoscale particle sizes and demonstrate significant potential in topical formulations. Alginate, a na...
Hybrid nanogels and their roles in eliminating soot stains from historical paper manuscripts
Hybrid nanogels and their roles in eliminating soot stains from historical paper manuscripts
Abstract
Soot stain from diverse sources is the most common stain that stains historical paper documents found in libraries, museums, and storage facilities. It is believ...
Formulasi Nanogel Kurkumin Berbasis Alginat Dialdehid
Formulasi Nanogel Kurkumin Berbasis Alginat Dialdehid
Abstract. Breast cancer is one of the leading causes of death among women in Indonesia. Current chemotherapy treatments often cause toxicity and have low drug bioavailability. This...
Pluronic F‐68 Enhanced Shoot Regeneration in Micropropagated Citrus Rootstock and Passiflora Species
Pluronic F‐68 Enhanced Shoot Regeneration in Micropropagated Citrus Rootstock and Passiflora Species
AbstractThe promotory effects have been studied of the non‐ionic surfactant, Pluronic F‐68, on bud induction/shoot regeneration in epicotyl and cotyledon explants of Citrus depress...
Synthesis and characterization of F127-Glu@ZnO nanogel material for cisplatin drug delivery application
Synthesis and characterization of F127-Glu@ZnO nanogel material for cisplatin drug delivery application
A novel F127-Glu@ZnO nanogel was synthesized for cisplatin delivery by functionalizing ZnO nanoparticles with L-glutamic acid (Glu) and grafting Pluronic onto Glu via urethane link...