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Biological Roles of Peptidases in Trypanosomatids
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In this review, we report the recent developments in the characterization of peptidases and their possible biological
functions in the Trypanosomatidae family. The focus will be on peptidases from Trypanosoma cruzi, Leishmania
spp., African trypanosomes and plant and insect trypanosomatids. There are numerous events in parasite development
where the involvement of peptidases has been established, and they will be approached in the present review. Also in this
review we will discuss the central roles have been proposed for peptidases in diverse processes such as virulence, host cell
interaction and invasion, catabolism of host proteins, differentiation, cell cycle progression and both stimulation and evasion
of host immune responses.
Title: Biological Roles of Peptidases in Trypanosomatids
Description:
In this review, we report the recent developments in the characterization of peptidases and their possible biological
functions in the Trypanosomatidae family.
The focus will be on peptidases from Trypanosoma cruzi, Leishmania
spp.
, African trypanosomes and plant and insect trypanosomatids.
There are numerous events in parasite development
where the involvement of peptidases has been established, and they will be approached in the present review.
Also in this
review we will discuss the central roles have been proposed for peptidases in diverse processes such as virulence, host cell
interaction and invasion, catabolism of host proteins, differentiation, cell cycle progression and both stimulation and evasion
of host immune responses.
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