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Pharmacogenetics and Pharmacogenomics
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This chapter traces the development of the science of pharmacogenetics and the clinical importance of polymorphisms of certain metabolic enzymes. It also examines the potential and challenges that the relatively new science of pharmacogenomics presents for the process of drug design. The science of pharmacogenetics has a long history dating back to the 1930s but was initially linked to empirical observations regarding, mainly, drug metabolism. The chapter distinguishes between cytochrome P450 2D6 (CYP2D6) polymorphism and cytochrome P450 2C9 (CYP2C9) polymorphism. It looks at methyltransferase polymorphism and idiosyncratic adverse drug reactions. Finally, the chapter considers phase II pharmacogenetics, before studying the clinical relevance of pharmacogenetics and pharmacogenomics.
Title: Pharmacogenetics and Pharmacogenomics
Description:
This chapter traces the development of the science of pharmacogenetics and the clinical importance of polymorphisms of certain metabolic enzymes.
It also examines the potential and challenges that the relatively new science of pharmacogenomics presents for the process of drug design.
The science of pharmacogenetics has a long history dating back to the 1930s but was initially linked to empirical observations regarding, mainly, drug metabolism.
The chapter distinguishes between cytochrome P450 2D6 (CYP2D6) polymorphism and cytochrome P450 2C9 (CYP2C9) polymorphism.
It looks at methyltransferase polymorphism and idiosyncratic adverse drug reactions.
Finally, the chapter considers phase II pharmacogenetics, before studying the clinical relevance of pharmacogenetics and pharmacogenomics.
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