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Effect of Ropivacaine Subcutaneous Infiltration on Surgical Skin Defects
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Background: Pain and the process of post-operative wound recovery are potential complications of surgery. No scientific evidence supports the claim that ropivacaine's infiltration effect on wound healing stimulates fibroblasts during the healing process and has an anti-inflammatory effect. This research aims to investigate the impact of ropivacaine infiltration on wound healing in experimental Wistar rats by quantifying fibroblasts.
Methods: This study was an experimental study using a sample of 32 Wistar rats (Rattus norvegicus), which were randomly divided into two groups, namely the treatment group with 2 cm full-thickness wound incisions with 1 ml of 0.2% ropivacaine infiltration, while the control group was given infiltration of 0.9% NaCl 1 ml. Furthermore, wound tissue samples were taken on day 5 to calculate fibroblasts.
Results: There were differences in the fibroblasts in the treatment group with ropivacaine infiltration and the group without infiltration (p = 0.00). The average number of fibroblasts in the control group was 29.13 per field of view, while the treatment group had 35.25.
Conclusion: Administration of ropivacaine affects fibroblasts of skin defects performed surgically in Wistar rats
Title: Effect of Ropivacaine Subcutaneous Infiltration on Surgical Skin Defects
Description:
Background: Pain and the process of post-operative wound recovery are potential complications of surgery.
No scientific evidence supports the claim that ropivacaine's infiltration effect on wound healing stimulates fibroblasts during the healing process and has an anti-inflammatory effect.
This research aims to investigate the impact of ropivacaine infiltration on wound healing in experimental Wistar rats by quantifying fibroblasts.
Methods: This study was an experimental study using a sample of 32 Wistar rats (Rattus norvegicus), which were randomly divided into two groups, namely the treatment group with 2 cm full-thickness wound incisions with 1 ml of 0.
2% ropivacaine infiltration, while the control group was given infiltration of 0.
9% NaCl 1 ml.
Furthermore, wound tissue samples were taken on day 5 to calculate fibroblasts.
Results: There were differences in the fibroblasts in the treatment group with ropivacaine infiltration and the group without infiltration (p = 0.
00).
The average number of fibroblasts in the control group was 29.
13 per field of view, while the treatment group had 35.
25.
Conclusion: Administration of ropivacaine affects fibroblasts of skin defects performed surgically in Wistar rats.
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