Comparative study of topical application of nanosilver and human placental extract on wound healing in rabbits

Background: The objective of the study was to study the comparative effect of topical application of nanosilver and human placental extract on wound healing in rabbits.Methods: 12 rabbits were randomly divided into two groups (n=6) and wound healing effect was observed in Excision model. Standard group was treated with topical human placental extract gel and test group was treated with topical Nanosilver cream. The mean percentage of the wound healed ‘within’ the group and ‘in between’ the groups were observed on day 3, 6, 9, 12, 15, 18, 21 and biopsy was done on day 21 for histopathological examination.Results: The mean percentage of wound contracted with Human placental extract vs nanosilver was 29.5 vs 35.7 on day3, 46.2 vs 53.5 on day 6, 61.5 vs 70.2 on day9, 74.2 vs 88.0 on day12, 89.5 vs 97.0 on day15, 96.7 vs 99.9 on day 18 and 99.9 vs 100 day 21 respectively. The mean percentage of the wound contracted when day1 compared to day21 was statistically significant (P value 0.0001) within the groups but in between the groups it was statistically non significant (P >0.05). There was an increase in collagen content and granulation tissue in the histopathological examination in both the groups on day 21.Conclusions: Wound healing effect of the Nanosilver was comparable to that of Human placental extract in excision wound model of rabbit.