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Thermо-induced Irreversible Changes of the Properties of Rats NADPH Oxidase
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It is known that FAD is an important cofactor for Nox isoform, as an
electron carrier from NADPH to Fe(III) of the heme group then to molecular
oxygen reducing it up to О2
[1, 6]. On the other hand, the thermostable Nox is
isolated from thermostable microorganisms [5]. However, the role of FAD as a
factor in changing the conformation and thermostability of Nox isoform has not
yet been determined.
The aim of the present work was to determine the corresponding
conditions under which the thermostability and production of superoxide
radicals are also observed in the absence of NADPH.
National Academy of Sciences of the Republic of Armenia
Title: Thermо-induced Irreversible Changes of the Properties of Rats NADPH Oxidase
Description:
It is known that FAD is an important cofactor for Nox isoform, as an
electron carrier from NADPH to Fe(III) of the heme group then to molecular
oxygen reducing it up to О2
[1, 6].
On the other hand, the thermostable Nox is
isolated from thermostable microorganisms [5].
However, the role of FAD as a
factor in changing the conformation and thermostability of Nox isoform has not
yet been determined.
The aim of the present work was to determine the corresponding
conditions under which the thermostability and production of superoxide
radicals are also observed in the absence of NADPH.
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