25-hydroxyvitamin D effect on cancer colon: Is visceral obesity the link?

Abstract Background: low 25-hydroxyvitamin have been identified in pathogenesis of colorectal cancer (CRC) with survival affection. Visceral fat tissue predisposes to chronic inflammation and release of growth factors that mediate colonic neoplasia.Aim of the work: to evaluate effect of vitamin D status and visceral obesity on cancer colon and to report the possible link between vitamin D and visceral obesity in those patients. Patients & Methods: Our patients were distributed in two groups; group 1 included cancer colon cases (no= 60) and 2nd group included control cases (no= 40). Clinical, anthropometric and pathological data were collected. Calculation of body mass index, visceral adiposity index (VAI) and detection of Vitamin D (25 OHD) serum level were performed to compare between groups. Results: There were significant differences in VAI and level of 25 OHD between both groups(P=0.011). We found significant higher prevalence of vitamin d deficiency in patient’ group [32 (53.3%) versus control group 13 (32.5%)]. There was a significant lower mean of VAI in vitamin D deficient patients versus non deficient cases (P=0.024). A significant different means of VAI and Vitamin D in patients’ group with different TNM stages. As higher stages associated with lower level of Vitamin D (P=0.027) and higher VAI (P=0.031)Conclusion: The vitamin D may augment the inflammatory status in visceral obesity which reported to be involved in tumourgenesis of cancer colon. Vitamin D deficiency may be a mediator between obesity and cancer and associated with higher tumour stage.